The Solubility Workflow, a start-to-finish profiling solution, enables precise and accurate measurement of the solubility of active pharmaceuticals or intermediates starting from solid forms.
The Symyx Solubility Workflow guides the lab process from creation of samples, through processing and work-up of samples, to analysis.
The workflow results in aggregated data that shows solubility profiles and enables detailed chromatogram analysis and overlays.
The Symyx Solubility Workflow is used to profile compounds versus media composition and temperature for Process Development Labs and to profile solubility versus pH or viscous media for Biopharmaceutical Development Labs.
- Design the study in Symyx Library Studio design software to cover both composition and experimental parameters
- Symyx Core Module dispenses solids and solutions, heats and cools samples, stirs, weighs, images, and measures pH
- Easily determine solubility in difficult to manipulate viscous vehicles (Tweens, PEGs, etc.) using Symyx Software modules and workflows
- Run hundreds of experiments in parallel, giving every sample the same treatment and processing to make comparisons more meaningful
- Screen binary and solvent systems for high-yield crystallization conditions
- Find crystallization systems that selectively exclude impurities
- Reduce waste costs and improve “Green Score” of process by screening environmentally favorable systems
- Track different dilution samples and flag best data using software data package
- Easily analyze multiple dilutions of hundreds of samples
- Profile API solubility vs. pH and temperature
